Preheat your grill or smoker to 300°F.
Wash and dry the jalapeños.
Instead of slicing the peppers completely in half, make a T-shaped cut in each jalapeño. Make a small slit across the top of the pepper without cutting all the way through, then make another cut lengthwise down the center.
Carefully open the pepper along the cuts and remove the seeds and inner membranes.Tip: Removing more of the white membrane will generally give you a milder Texas Twinkie. Leave some behind if you want more heat. Add the 2 ½ cups chopped brisket and 1 ⅓ cups shredded pepper jack cheese to a large bowl.
Mix until the brisket and cheese are evenly combined.
Carefully stuff each prepared jalapeño with the brisket and pepper jack mixture.
Pack the filling inside without forcing so much into the pepper that it splits.
Wrap one full slice of bacon around each stuffed jalapeño.
Secure the bacon with one or more toothpicks as needed to keep everything together while it cooks.
Place the stuffed and wrapped jalapeños directly on the smoker or grill.
Cook at 300°F for approximately 60 minutes, or until the bacon is cooked to your liking, the jalapeños have softened, and the filling is hot and melted.
Remove the Texas Twinkies from the smoker and allow them to cool slightly before serving.Remember to remove the toothpicks before eating. Enjoy!